Hitting the brakes: how PD-1 stops T cells from fighting
PD-1 is part of a group of proteins that helps promote balance during an immune response. Together, these are known as immune checkpoints. These “break” proteins help decrease the function of our T cell soldiers, which is good as we don’t want our great fighters killing when there is nothing to kill.
T regulatory cells: the firefighters of the immune system
It was like a quiet summer day until one of your internal fighters decided to attack and kill some of your healthy cells. But it doesn’t stop there. The death of these cells starts a “fire”. That is when the T regulatory cells come into action!
I’m not lazy, it’s called selective participation – Explaining T cell anergy
Our internal mechanism of defence (known as the immune system) is made of many different cell types that together help protect us against infections and cancer. Today we are talking (again) about my favourite cell type, called T cell. To do their job, they need to receive specific signals allowing them to be activated and ready to […]
Do T cells ever get “tired”? An introduction to T cell exhaustion
Two weeks ago I did a road trip with my (now) fiancé and our beautiful dog. We visited cities in New Brunswick, Prince Edward Island and Nova Scotia. We had an amazing time, but as soon as we got home there were a million chores to do (unpacking, laundry, groceries, etc). I was so tired […]
The thymus: from earth to space
Guess what, today I’m going to talk about the coolest organ of them all, one that does not get as much attention as it deserves (some bias was added to this sentence). This organ ensures the development of our immune cells which are specialized in fighting infection and cancer. Yes, we will be talking about […]
Our Internal “Immune GPS”
Do you remember the last time you had to go to a new place but didn’t know the way? You probably had no issue finding the path to reach your expected destination. Today, our phones will act as GPS and provide us with precise directions to go from point A to point B. Easy, right? […]
Could you please be tolerant? How the immune system prevents autoimmune diseases
If you are a little bit like me, you have also spent a lot of time trying to figure out how exactly our body is able to function the way it does. Picture this. The immune system is your internal defence mechanism, in order to provide you with the correct level of protection, it needs […]
‘Hasta la vista, baby’: CD8 T cell, the killer machine of the immune system
Today I decided to present the role of the coolest immune cell of all. This cell has the ability to kill cells that are infected with virus or bacteria. Now that we already have a general idea of how an immune response works (recognize, remove, remember and repeat) I will start giving you some extra […]
“Gotta Catch ‘Em All”: How immune cells recognize every single pathogen
Think about the number of every single microorganism you have encountered since you were born. Now add to that, all the possible microorganisms you will encounter in the future. If that sounds like a lot, you are completely correct! Now, if you remember from my previous post, I mentioned that our immune cells are able […]
